Together with Dr Nathan Lo, I run the “Molecular Ecology, Evolution, and Phylogenetics” research group.
It is important to understand under which circumstances to use which model and when molecular calibration works.
They generalized this observation to assert that the rate of evolutionary change of any specified protein was approximately constant over time and over different lineages (based on the molecular clock hypothesis (MCH)).
The genetic equidistance phenomenon was first noted in 1963 by Emanuel Margoliash, who wrote: "It appears that the number of residue differences between cytochrome c of any two species is mostly conditioned by the time elapsed since the lines of evolution leading to these two species originally diverged.
NELSI is implemented in the R programming language, and it is available as a package in github.
It is compatible with some popular phylogenetic packages in R, such as Ape (Popescu .